Flying with kids???? Help Please!!!!

I am thinking about flying with my two kids to Colorado to visit family. I am not sure if this is a good idea or not. I don't know how the kids will handle flying and then the car ride to their house. I also don't know how they will be away from home and daddy. Since my husband doesn't have any vacation he will not be traveling with us. I know I can do this by myself. I am just worried it might be to much for the kids. On the other hand they might have a blast. Does anyone with experience traveling with kids have any ideas or suggestions????